Comparative Analysis of Complexed PSA, Free PSA and Their Ratio in Detecting Prostate Cancer
Koji Okihara; Carol D. Chell; Alan W. Partin; Herbert A. Fritche; Daniel W. Chan; Lori J. Sokoll; Michael K. Brawer, et al.
The Journal of Urology, May 2002
This study concludes that the combination of percent free PSA and PSA is superior to complexed PSA. In a study of 354 men who were receiving biopsies for prostate cancer, the authors compared the performance of percent free PSA (fPSA) and complexed PSA (cPSA). They wanted to see if one was better than the other for improving the accuracy of the standard PSA test, also called total PSA. The research showed that fPSA does in fact improve the accuracy of total PSA for detecting prostate cancer, while cPSA does not. cPSA did not detect any more cancers than did the tPSA test.
PSA and Free-PSA Testing for Prostate Cancer Is Still a Lifesaver
William J. Catalona, M.D; Jack A. Maggiore, Ph.D.
Clinical Lab Products, February 2005
The authors state that while understanding of the total PSA test continues to evolve, this popular prostate cancer screen is still the most specific cancer detector available. In fact, the PSA test is even more specific than mammograms are for detecting early-stage breast cancer. The authors also assert that the test for percent free PSA (fPSA) remains a valued follow-up test for PSA. In men whose PSA levels are high, fPSA can improve the accuracy of PSA and help many men avoid unnecessary biopsies. Finally, the authors suggest improved uses for the PSA test, including evaluating trends over time.
Percentage of Free PSA in Black Vs. White Men for Detection and Staging Of Prostate Cancer: A Prospective Multicenter Clinical Trial
W.J. Catalona; A.W. Partin; K.M. Slawin; C.K. Naughton; M.K. Brawer; R.C. Flanigan, et al.
Urology, March 2000
This study evaluated whether the Hybritech percent free PSA calculation performed equally well in a black population as in a white population, and whether the assay was useful in predicting the stage and grade of prostate cancer in blacks. Researchers found that the percent free PSA determination was in fact as accurate in a black population.
Comparison of Percent free PSA, PSA Density, and Age-Specific PSA Cutoffs for Prostate Cancer Detection and Staging
W.J. Catalona; P.C. Southwick; K.M. Slawin; A.W. Partin; M.K. Brawer; R.C. Flanigan, et al.
Urology, August 2000
This study involving 773 men examined three follow-up methods for ensuring that the results of a patient’s total PSA test were accurate. The three techniques were age-specific PSA reference ranges, PSA density (PSAD), and percent free PSA. Researchers found that the percent free PSA determination was significantly better at detecting prostate cancer than were age-specific PSA reference ranges. Percent free PSA and PSA density provided equally accurate results. Researchers concluded that the free PSA assay may be used in place of PSAD to determine whether a biopsy was necessary and to help make treatment decisions, because the free PSA assay does not require a more costly ultrasound.
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