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Since the first publication of the DNA double helical structure, electrophoresis
has been a standard among the analytical tools used for nucleic acid analysis. Capillary
electrophoresis (CE) technology extends the power of electrophoresis by using a format
that incorporates direct detection, automation and the ability to study interactions in
solution.
With Beckman Coulter CE technology, you are able to analyze a molecule
as it behaves in free solution. This is possible with the high sensitivity of
laser-induced fluorescence (LIF) and direct on-line quantitation. With the addition of
polymers, the capillary tube can be further transformed into a sieving environment,
allowing nucleic acids to be separated by size.
A single instrument platform can be used to quantitatively assess
oligonucleotide purity, accurately measure gene expression, quantify viral load, study
DNA-Protein interactions, and separate nucleic acid fragments for applications such as
genotyping and mutation analysis.
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